魁北克北部萨格奈–圣让湖地区由于长期交通不便，该地区近30万居民大多是18世纪不足数千名法国移民的后代。奠基者效应使得这一地区若干遗传病的发病率远超全国其他地区，20%的该地区居民携带至少一种罕见的遗传病等位基因，如酪氨酸血症，Leigh综合征等。
https://jmg.bmj.com/content/58/10/653
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The global forecast for the Asian markets is murky following recent volatility, with crude oil prices providing support in what has been an otherwise tough month. The European markets were down and the U.S. bourses were mixed and flat and the Asian markets figure to split the difference.The TSE finished modestly lower on Friday following losses from the financial shares and property stocks.For the day, the index sank 15.09 points or 0.49 percent to finish at 3,061.35 after trading between 3,057.84 and 3,089.78. Volume was 1.39 billion shares worth 1.30 billion Singapore dollars. There were 285 decliners and 184 gainers.
For some time, Mr. Durov and a few dozen staffers had no fixed headquarters, but rather traveled the world, setting up shop in one city after another, he told the Journal in 2016. The company now has its operational base in Dubai, though it says it doesn’t keep servers there.Mr. Durov maintains a yearslong friendship from his VK days with actor and tech investor Jared Leto, with whom he shares an ascetic lifestyle that eschews meat and alcohol.
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