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癌症疫苗让小鼠恢复活力但会对人类有效吗?

2025-02-11 00:07 by 世界主宰

化疗和放疗让大部分儿童癌症患者都能活下来,但他们付出了巨大代价。很多人会早逝于心脏病、中风或继发性癌症等慢性疾病,原因是他们的细胞更快衰老。科学家发现儿童癌症幸存者在 30 岁时其细胞衰老程度已经类似 70 多岁和 80 多岁的老年人。而且随着时间的推移,情况会愈来愈严重。过去十年,被称为 senolytics 的药物被证明能消除小鼠的衰老细胞。senolytics 药物包括了化疗药物 dasatinib,以及广泛存在于果蔬中的天然化合物 quercetin 和 fisetin。现在科学家招募 50-60 名已呈现衰老迹象的儿童癌症幸存者,他们的平均年龄 40 岁,参与者将接受口服剂量的 dasatinib、quercetin 或 fisetin,观察这些药物能否在六个月内改善身体机能。然后每五年进行一次跟踪,以评估是否有助于延长预期寿命。这是 senolytics 能否用于延长老年人健康寿命的第一步。

Guardian:Anti-ageing jabs – they can rejuvenate mice, but will they work on humans?

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癌症疫苗让小鼠恢复活力但会对人类有效吗?

2025-02-11 00:07 by 世界主宰

化疗和放疗让大部分儿童癌症患者都能活下来,但他们付出了巨大代价。很多人会早逝于心脏病、中风或继发性癌症等慢性疾病,原因是他们的细胞更快衰老。科学家发现儿童癌症幸存者在 30 岁时其细胞衰老程度已经类似 70 多岁和 80 多岁的老年人。而且随着时间的推移,情况会愈来愈严重。过去十年,被称为 senolytics 的药物被证明能消除小鼠的衰老细胞。senolytics 药物包括了化疗药物 dasatinib,以及广泛存在于果蔬中的天然化合物 quercetin 和 fisetin。现在科学家招募 50-60 名已呈现衰老迹象的儿童癌症幸存者,他们的平均年龄 40 岁,参与者将接受口服剂量的 dasatinib、quercetin 或 fisetin,观察这些药物能否在六个月内改善身体机能。然后每五年进行一次跟踪,以评估是否有助于延长预期寿命。这是 senolytics 能否用于延长老年人健康寿命的第一步。

Guardian:Anti-ageing jabs – they can rejuvenate mice, but will they work on humans?

#科学

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Telegram has made it easier for its users to communicate, as it has introduced a feature that allows more than 200,000 users in a group chat. However, if the users in a group chat move past 200,000, it changes into "Broadcast Group", but the feature comes with a restriction. Groups with close to 200k members can be converted to a Broadcast Group that allows unlimited members. Only admins can post in Broadcast Groups, but everyone can read along and participate in group Voice Chats," Telegram added.

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