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细胞新图谱揭示关键DNA对癌症进化的作用

美国希望之城国家医疗中心研究团队绘制出创新细胞图谱,揭示了染色体外DNA(ecDNA)在癌症进化中的关键作用。研究表明,ecDNA可预测致癌基因如何重塑DNA结构并改变肿瘤微环境,特别是引发缺氧状态,与癌症进展和治疗耐药性密切相关。通过空间转录组学和基因组数据分析,研究识别出不同细胞群落及其演化路径,为精准医疗提供了重要数据支持,未来有望应用于各类癌症的个性化治疗。研究成果强调了理解ecDNA分子行为对发现治疗靶点和评估癌症复发风险的重要性。

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细胞新图谱揭示关键DNA对癌症进化的作用 中国科技网/央视新闻
细胞新图谱揭示关键DNA对癌症进化的作用 有助研发更个性化更具针对性疗法 财联社

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细胞新图谱揭示关键DNA对癌症进化的作用

美国希望之城国家医疗中心研究团队绘制出创新细胞图谱,揭示了染色体外DNA(ecDNA)在癌症进化中的关键作用。研究表明,ecDNA可预测致癌基因如何重塑DNA结构并改变肿瘤微环境,特别是引发缺氧状态,与癌症进展和治疗耐药性密切相关。通过空间转录组学和基因组数据分析,研究识别出不同细胞群落及其演化路径,为精准医疗提供了重要数据支持,未来有望应用于各类癌症的个性化治疗。研究成果强调了理解ecDNA分子行为对发现治疗靶点和评估癌症复发风险的重要性。

媒体报道
细胞新图谱揭示关键DNA对癌症进化的作用 中国科技网/央视新闻
细胞新图谱揭示关键DNA对癌症进化的作用 有助研发更个性化更具针对性疗法 财联社

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