上海交大发布Venus，可让蛋白质“定向进化”
上海交通大学洪亮团队发布大模型Venus，通过AI实现蛋白质功能的“定向进化”，可高效预测和设计蛋白质功能，将蛋白质生产从试错转为精准设计。该模型已助力多款蛋白质产业化，用于阿尔兹海默等疾病的诊断。
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上海交大发布大模型Venus，可让蛋白质“定向进化” 界面
上海交大发布Venus 可让蛋白质“定向进化” 格隆汇/财联社/新浪科技
上海交大发布Venus，可让蛋白质“定向进化” 钛媒体
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The super secure UAE-based Telegram messenger service, developed by Russian-born software icon Pavel Durov, is looking to raise $1bn through a bond placement to a limited number of investors from Russia, Europe, Asia and the Middle East, the Kommersant daily reported citing unnamed sources on February 18, 2021.The issue reportedly comprises exchange bonds that could be converted into equity in the messaging service that is currently 100% owned by Durov and his brother Nikolai.Kommersant reports that the price of the conversion would be at a 10% discount to a potential IPO should it happen within five years.The minimum bond placement is said to be set at $50mn, but could be lowered to $10mn. Five-year bonds could carry an annual coupon of 7-8%.
A spike in interest rates since the start of the year has accelerated a rotation out of high-growth technology stocks and into value stocks poised to benefit from a reopening of the economy. The Nasdaq has fallen more than 10% over the past month as the Dow has soared to record highs, with a spike in the 10-year US Treasury yield acting as the main catalyst. It recently surged to a cycle high of more than 1.60% after starting the year below 1%. But according to Jim Paulsen, the Leuthold Group's chief investment strategist, rising interest rates do not represent a long-term threat to the stock market. Paulsen expects the 10-year yield to cross 2% by the end of the year. A spike in interest rates and its impact on the stock market depends on the economic backdrop, according to Paulsen. Rising interest rates amid a strengthening economy "may prove no challenge at all for stocks," Paulsen said.
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