Natural Killer cells (NK cells) are a class of lymphocytes which act against malignant cells and virus infected cells,
• Natural killer cells belong to innate immunity. ◦ NK cells lack antigen specific receptors and are referred to as Large granular lymphocytes. (LGL) ◦ NK cells are identified by CD16 and CD56 cell surface receptors . NK cell activity is augmented by interferons and upon activation, they release perforins and granzymes and express Fas L
The common feature of both cytotoxic T-cells and NK cells is effectivity against virus-infected cells.
The difference is however that cytotoxic T-cell is MHC- I restricted while NK cell is NK cells adapt accordingly to the presence or absence of MHC class I molecules.
Changes in steady state MHC expression can lead to gain or loss of responsiveness in NK cells, but the inflammatory conditions associated with infections act to sustain a higher state of responsiveness, enabling initially hyporesponsive NK cells to provide protective activity, and to do so without being subject to inhibition by self MHC I molecule
Natural Killer cells (NK cells) are a class of lymphocytes which act against malignant cells and virus infected cells,
• Natural killer cells belong to innate immunity. ◦ NK cells lack antigen specific receptors and are referred to as Large granular lymphocytes. (LGL) ◦ NK cells are identified by CD16 and CD56 cell surface receptors . NK cell activity is augmented by interferons and upon activation, they release perforins and granzymes and express Fas L
The common feature of both cytotoxic T-cells and NK cells is effectivity against virus-infected cells.
The difference is however that cytotoxic T-cell is MHC- I restricted while NK cell is NK cells adapt accordingly to the presence or absence of MHC class I molecules.
Changes in steady state MHC expression can lead to gain or loss of responsiveness in NK cells, but the inflammatory conditions associated with infections act to sustain a higher state of responsiveness, enabling initially hyporesponsive NK cells to provide protective activity, and to do so without being subject to inhibition by self MHC I molecule
BY Microbiology
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