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世界首例基因编辑猪肝移植人体成功 为器官短缺提供突破性方案

中科院院士窦科峰团队利用经6处基因编辑的猪肝脏,移植至一名脑死亡但体征稳定的患者体内,同时保留其自身肝脏以模拟肝衰竭支持治疗。移植后10天观察期内,猪肝在人体内正常分泌胆汁、血供稳定,未出现超急性排斥反应及猪内源性逆转录病毒传播。该成果获《自然》杂志认定为异种器官移植领域里程碑。

研究严格遵循学术及伦理审查程序,移植对象为家属同意参与的脑死亡患者,实验在伦理委员会监督下完成,10天后因家属意愿终止。此前,基因编辑猪心脏、肾脏移植人体的案例已逐步推进,但肝脏移植因血液供应复杂性更具挑战。

牛津大学教授彼得·弗兰德称该技术“非常精妙”,为临床应用奠定基础。通过基因编辑技术减少免疫排斥风险,异种移植或成解决全球器官短缺的关键路径。

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世界首例基因编辑猪肝移植人体成功 为器官短缺提供突破性方案

中科院院士窦科峰团队利用经6处基因编辑的猪肝脏,移植至一名脑死亡但体征稳定的患者体内,同时保留其自身肝脏以模拟肝衰竭支持治疗。移植后10天观察期内,猪肝在人体内正常分泌胆汁、血供稳定,未出现超急性排斥反应及猪内源性逆转录病毒传播。该成果获《自然》杂志认定为异种器官移植领域里程碑。

研究严格遵循学术及伦理审查程序,移植对象为家属同意参与的脑死亡患者,实验在伦理委员会监督下完成,10天后因家属意愿终止。此前,基因编辑猪心脏、肾脏移植人体的案例已逐步推进,但肝脏移植因血液供应复杂性更具挑战。

牛津大学教授彼得·弗兰德称该技术“非常精妙”,为临床应用奠定基础。通过基因编辑技术减少免疫排斥风险,异种移植或成解决全球器官短缺的关键路径。

新华社
Nature

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在花软件新闻投稿频道 Telegram | DID YOU KNOW?

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Export WhatsApp stickers to Telegram on iPhone

You can’t. What you can do, though, is use WhatsApp’s and Telegram’s web platforms to transfer stickers. It’s easy, but might take a while.Open WhatsApp in your browser, find a sticker you like in a chat, and right-click on it to save it as an image. The file won’t be a picture, though—it’s a webpage and will have a .webp extension. Don’t be scared, this is the way. Repeat this step to save as many stickers as you want.Then, open Telegram in your browser and go into your Saved messages chat. Just as you’d share a file with a friend, click the Share file button on the bottom left of the chat window (it looks like a dog-eared paper), and select the .webp files you downloaded. Click Open and you’ll see your stickers in your Saved messages chat. This is now your sticker depository. To use them, forward them as you would a message from one chat to the other: by clicking or long-pressing on the sticker, and then choosing Forward.

Telegram has exploded as a hub for cybercriminals looking to buy, sell and share stolen data and hacking tools, new research shows, as the messaging app emerges as an alternative to the dark web.An investigation by cyber intelligence group Cyberint, together with the Financial Times, found a ballooning network of hackers sharing data leaks on the popular messaging platform, sometimes in channels with tens of thousands of subscribers, lured by its ease of use and light-touch moderation.在花软件新闻投稿频道 from no


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